Identification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity
ABSTRACTAspartic acid (Asp) isomerization is a spontaneous non-enzymatic post-translation modification causing a change in the structure of the protein backbone, which is commonly observed in therapeutic antibodies during manufacturing and storage. The Asps in Asp-Gly (DG), Asp-Ser (DS), and Asp-Thr...
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Taylor & Francis Group,
2023-12-01T00:00:00Z.
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