Calibration and validation of the rabbit model of electrolytic‐mediated arterial thrombosis against the standard‐of‐care anticoagulant apixaban

Abstract Apixaban is a factor Xa (FXa) inhibitor and standard‐of‐care anticoagulant with FXa Ki and plasma protein binding (free fraction) averages 0.08 nM and 0.13 in humans and 0.16 nM and 0.37 in rabbits, respectively. Apixaban at the approved dose of 5 mg BID achieved maximum and minimum plasma...

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Main Authors: Pancras C. Wong (Author), Earl Crain (Author)
Format: Book
Published: Wiley, 2022-06-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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