Effects of changing the timing of warfarin administration in combination with fluconazole on prolongation of the PT-INR: a case report

• Glavni autori: Hayato Akamatsu (Autor), Hiroo Nakagawa (Autor), Ichiro Matsumaru (Autor), Junya Hashizume (Autor), Hitomi Harasawa (Autor), Yukinobu Kodama (Autor), Takashi Miura (Autor), Kaname Ohyama (Autor)
• Format: Knjiga
• Izdano: BMC, 2023-04-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Background Fluconazole (FLCZ) inhibits cytochrome P450 (CYP) 2C9, 2C19, and 3A4 and has a drug-drug interaction that potentiates the effects of warfarin and prolong the prothrombin time-international normalized ratio (PT-INR). Although a drug-drug interaction have been reported between FLCZ...