Effects of changing the timing of warfarin administration in combination with fluconazole on prolongation of the PT-INR: a case report

• Main Authors: Hayato Akamatsu (Author), Hiroo Nakagawa (Author), Ichiro Matsumaru (Author), Junya Hashizume (Author), Hitomi Harasawa (Author), Yukinobu Kodama (Author), Takashi Miura (Author), Kaname Ohyama (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Fluconazole (FLCZ) inhibits cytochrome P450 (CYP) 2C9, 2C19, and 3A4 and has a drug-drug interaction that potentiates the effects of warfarin and prolong the prothrombin time-international normalized ratio (PT-INR). Although a drug-drug interaction have been reported between FLCZ...