Dual epigenetic changes in diabetes mellitus‐associated pancreatic ductal adenocarcinoma correlate with downregulation of E‐cadherin and worsened prognosis

• Main Authors: Yutaro Hara (Author), Hiroki Mizukami (Author), Keisuke Yamazaki (Author), Takahiro Yamada (Author), Akiko Igawa (Author), Yuki Takeuchi (Author), Takanori Sasaki (Author), Hanae Kushibiki (Author), Kotaro Murakami (Author), Kazuhiro Kudoh (Author), Keinosuke Ishido (Author), Kenichi Hakamada (Author)
• Format: Book
• Published: Wiley, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Diabetes mellitus (DM) is a risk factor for pancreatic ductal adenocarcinoma (PDAC) that promotes the promoter methylation of CDH1. It is still unclear whether DM can exert other epigenetic effects, such as altering microRNA (miR) expression, in PDAC. The expression of miR‐100‐5p is known t...