In Vivo Validation of Spray-Dried Mesoporous Bioactive Glass Microspheres Acting as Prolonged Local Release Systems for BMP-2 to Support Bone Regeneration

• Main Authors: Julia C. Berkmann (Author), Aaron X. Herrera Martin (Author), Carlotta Pontremoli (Author), Kai Zheng (Author), Christian H. Bucher (Author), Agnes Ellinghaus (Author), Aldo R. Boccaccini (Author), Sonia Fiorilli (Author), Chiara Vitale Brovarone (Author), Georg N. Duda (Author), Katharina Schmidt-Bleek (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bone morphogenetic protein-2 (BMP-2) is a known key mediator of physiological bone regeneration and is clinically approved for selected musculoskeletal interventions. Yet, broad usage of this growth factor is impeded due to side effects that are majorly evoked by high dosages and burst release kinet...