Janus kinase (JAK) inhibitors in the treatment of neoplastic and inflammatory disorders
The Janus kinase (JAK) family of nonreceptor protein-tyrosine kinases consists of JAK1, JAK2, JAK3, and TYK2 (Tyrosine Kinase 2). Each of these proteins contains a JAK homology pseudokinase (JH2) domain that interacts with and regulates the activity of the adjacent protein kinase domain (JH1). The J...
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Elsevier,
2022-09-01T00:00:00Z.
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