Design and Synthesis of Novel N-Arylsulfonyl-3-(2-yl-ethanone)-6-methylindole Derivatives as Inhibitors of HIV-1 Replication

• Main Authors: Zhiping Che (Author), Shengming Liu (Author), Yuee Tian (Author), Zhenjie Hu (Author), Yingwu Chen (Author), Genqiang Chen (Author)
• Format: Book
• Published: MDPI AG, 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Seven novel N-arylsulfonyl-3-(2-yl-ethanone)-6-methylindole derivatives 4a-f and 6 were readily synthesized and have been identified as inhibitors of human immunodeficiency virus type-1 (HIV-1) replication. Initial biological studies indicated that among these derivatives, N-(p-ethyl)phenylsulfonyl-...