PKR Promotes Oxidative Stress and Apoptosis of Human Articular Chondrocytes by Causing Mitochondrial Dysfunction through p38 MAPK Activation-PKR Activation Causes Apoptosis in Human Chondrocytes

• Main Authors: Ching-Hou Ma (Author), Chin-Hsien Wu (Author), I-Ming Jou (Author), Yuan-Kun Tu (Author), Ching-Hsia Hung (Author), Wan-Ching Chou (Author), Yun-Ching Chang (Author), Pei-Ling Hsieh (Author), Kun-Ling Tsai (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoarthritis (OA) is one of the most common types of arthritis in the elderly people. It has been known that chondrocyte apoptosis occurs in OA cartilage; however, the detailed molecular mechanism remains unclear. In the current study, we aimed to elucidate the role of double-stranded RNA-dependen...