Exon skipping of TGFβRI affects signalling and ECM expression in hypertrophic scar-derived fibroblasts

• Main Authors: Rajiv S Raktoe (Author), Marion H Rietveld (Author), Jacoba J Out-Luiting (Author), Marianna Kruithof-de Julio (Author), Paul PM van Zuijlen (Author), Remco van Doorn (Author), Abdoelwaheb El Ghalbzouri (Author)
• Format: Book
• Published: SAGE Publishing, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: In burn patients, wound healing is often accompanied by hypertrophic scar (HS) development, resulting in both functional and aesthetic problems. HSs are characterised by abundant presence of myofibroblasts that contribute to overproduction of extracellular matrix (ECM) that is regulated...