An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads: Experimental studies and molecular dynamics analysis

• Main Authors: Jamie Anne Lugtu-Pe (Author), Xuning Zhang (Author), Sako Mirzaie (Author), Hao Han R. Chang (Author), Nour AL-Mousawi (Author), Kuan Chen (Author), Yongqiang Li (Author), Anil Kane (Author), Daniel Bar-Shalom (Author), Xiao Yu Wu (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate. However, most new chemical entities exhibit poor water solubility, and hence are exempt from such benefits. Although combining drug amorphization with co...