Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats

• Main Authors: Chiyuan Ma (Author), Xiaopeng Zhou (Author), Kai Xu (Author), Linyan Wang (Author), Yute Yang (Author), Wei Wang (Author), An Liu (Author), Jisheng Ran (Author), Shigui Yan (Author), Haobo Wu (Author), Lidong Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As a chronic disease, osteoarthritis (OA) leads to the degradation of both cartilage and subchondral bone, its development being mediated by proinflammatory cytokines like interleukin-1β. In the present study, the anti-inflammatory effect of specnuezhenide (SPN) in OA and its underlying mechanism we...