Population Pharmacokinetic/Pharmacodynamic Analysis of Nociceptive Pain Models Following an Oral Pregabalin Dose Administration to Healthy Subjects

• المؤلفون الرئيسيون: Michiel J. vanEsdonk (مؤلف), Ian Lindeman (مؤلف), Pieter Okkerse (مؤلف), Marieke L. deKam (مؤلف), Geert J. Groeneveld (مؤلف), Jasper Stevens (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2018-09-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

A battery of pain models can be used in clinical trials to investigate the efficacy and to establish the concentration‐effect relationship of novel analgesics. This study quantified the pharmacokinetics (PK) of pregabalin after a single oral dose of 300 mg and the pharmacodynamics (PD) on the pain t...