Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formation

• Main Authors: Chun-Chi Chou (Author), Kuo-Tai Hua (Author), Min-Wei Chen (Author), Chin-Jui Wu (Author), Chun-Hua Hsu (Author), Jann-Tay Wang (Author), Michael Hsiao (Author), Lin-Hung Wei (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The functional interleukin 6 (IL-6) signaling complex is a hexameric structure composed of IL-6, IL-6Rα, and the signaling receptor gp130. There are three different modes of IL-6 signaling, classic signaling, trans-signaling, and trans-presentation, which are not functionally redundant and mediate p...