ABT-333 (Dasabuvir) Increases Action Potential Duration and Provokes Early Afterdepolarizations in Canine Left Ventricular Cells via Inhibition of I_Kr

• Main Authors: Zsigmond Máté Kovács (Author), József Óvári (Author), Csaba Dienes (Author), János Magyar (Author), Tamás Bányász (Author), Péter P. Nánási (Author), Balázs Horváth (Author), Adam Feher (Author), Zoltan Varga (Author), Norbert Szentandrássy (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABT-333 (dasabuvir) is an antiviral agent used in hepatitis C treatment. The molecule, similarly to some inhibitors of hERG channels, responsible for the delayed rectifier potassium current (I_Kr), contains the methanesulfonamide group. Reduced I_Kr curren...