Mitochondria-targeted hydrogen sulfide donor reduces fatty liver and obesity in mice fed a high fat diet by inhibiting de novo lipogenesis and inflammation via mTOR/SREBP-1 and NF-κB signaling pathways

• Päätekijät: Aneta Stachowicz (Tekijä), Klaudia Czepiel (Tekijä), Anna Wiśniewska (Tekijä), Kamila Stachyra (Tekijä), Magdalena Ulatowska-Białas (Tekijä), Beata Kuśnierz-Cabala (Tekijä), Marcin Surmiak (Tekijä), Grzegorz Majka (Tekijä), Katarzyna Kuś (Tekijä), Mark E. Wood (Tekijä), Roberta Torregrossa (Tekijä), Matthew Whiteman (Tekijä), Rafał Olszanecki (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2024-11-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Metabolic diseases that include obesity and metabolic-associated fatty liver disease (MAFLD) are a rapidly growing worldwide public health problem. The pathogenesis of MAFLD includes abnormally increased lipogenesis, chronic inflammation, and mitochondrial dysfunction. Mounting evidence suggests tha...