Mitochondria-targeted hydrogen sulfide donor reduces fatty liver and obesity in mice fed a high fat diet by inhibiting de novo lipogenesis and inflammation via mTOR/SREBP-1 and NF-κB signaling pathways

• Główni autorzy: Aneta Stachowicz (Autor), Klaudia Czepiel (Autor), Anna Wiśniewska (Autor), Kamila Stachyra (Autor), Magdalena Ulatowska-Białas (Autor), Beata Kuśnierz-Cabala (Autor), Marcin Surmiak (Autor), Grzegorz Majka (Autor), Katarzyna Kuś (Autor), Mark E. Wood (Autor), Roberta Torregrossa (Autor), Matthew Whiteman (Autor), Rafał Olszanecki (Autor)
• Format: Książka
• Wydane: Elsevier, 2024-11-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Metabolic diseases that include obesity and metabolic-associated fatty liver disease (MAFLD) are a rapidly growing worldwide public health problem. The pathogenesis of MAFLD includes abnormally increased lipogenesis, chronic inflammation, and mitochondrial dysfunction. Mounting evidence suggests tha...