Mitochondria-targeted hydrogen sulfide donor reduces fatty liver and obesity in mice fed a high fat diet by inhibiting de novo lipogenesis and inflammation via mTOR/SREBP-1 and NF-κB signaling pathways

• Main Authors: Aneta Stachowicz (Author), Klaudia Czepiel (Author), Anna Wiśniewska (Author), Kamila Stachyra (Author), Magdalena Ulatowska-Białas (Author), Beata Kuśnierz-Cabala (Author), Marcin Surmiak (Author), Grzegorz Majka (Author), Katarzyna Kuś (Author), Mark E. Wood (Author), Roberta Torregrossa (Author), Matthew Whiteman (Author), Rafał Olszanecki (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metabolic diseases that include obesity and metabolic-associated fatty liver disease (MAFLD) are a rapidly growing worldwide public health problem. The pathogenesis of MAFLD includes abnormally increased lipogenesis, chronic inflammation, and mitochondrial dysfunction. Mounting evidence suggests tha...