Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model

• Main Authors: Yiwen Yao (Author), Felix Ritzmann (Author), Sarah Miethe (Author), Kathrin Kattler-Lackes (Author), Betül Colakoglu (Author), Christian Herr (Author), Andreas Kamyschnikow (Author), Michelle Brand (Author), Holger Garn (Author), Daniela Yildiz (Author), Frank Langer (Author), Robert Bals (Author), Christoph Beisswenger (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Impaired interaction of fibroblasts with pneumocytes contributes to the progression of chronic lung disease such as idiopathic pulmonary fibrosis (IPF). Mucin 5B (MUC5B) is associated with IPF. Here we analyzed the interaction of primary fibroblasts and alveolar type 2 (AT2) pneumocytes in...