Characterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody

• Main Authors: Dario A. T. Cramer (Author), Vojtech Franc (Author), Anna-Katharina Heidenreich (Author), Michaela Hook (Author), Mahdi Adibzadeh (Author), Dietmar Reusch (Author), Albert J. R. Heck (Author), Markus Haberger (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTThe development of increasingly complex antibody formats, such as bispecifics, can lead to the formation of increasingly complex high- and low-molecular-weight by-products. Here, we focus on the characterization of high molecular weight species (HMWs) representing the highest complexity of s...