DuCLOX-2/5 Inhibition Attenuates Inflammatory Response and Induces Mitochondrial Apoptosis for Mammary Gland Chemoprevention

• Main Authors: Swetlana Gautam (Author), Atul K. Rawat (Author), Shreesh R. Sammi (Author), Subhadeep Roy (Author), Manjari Singh (Author), Uma Devi (Author), Rajnish K. Yadav (Author), Lakhveer Singh (Author), Jitendra K. Rawat (Author), Mohd N. Ansari (Author), Abdulaziz S. Saeedan (Author), Dinesh Kumar (Author), Rakesh Pandey (Author), Gaurav Kaithwas (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study is a pursuit to define implications of dual cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention. The monotherapy and combination therapy of zaltoprofen (COX-2 inhibitor) and zileuton (5-LOX inhibi...