A novel cardiovascular systems model to quantify drugs effects on the inter‐relationship between contractility and other hemodynamic variables

• Main Authors: Yu Fu (Author), Hadi Taghvafard (Author), Medhat M. Said (Author), Eric I. Rossman (Author), Teresa A. Collins (Author), Stéphanie Billiald‐Desquand (Author), Derek Leishman (Author), Piet H. van derGraaf (Author), J. G. Coen vanHasselt (Author), Nelleke Snelder (Author)
• Format: Book
• Published: Wiley, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The use of systems‐based pharmacological modeling approaches to characterize mode‐of‐action and concentration‐effect relationships for drugs on specific hemodynamic variables has been demonstrated. Here, we (i) expand a previously developed hemodynamic system model through integration of ca...