Effects of <i>Escherichia coli</i> LPS Structure on Antibacterial and Anti-Endotoxin Activities of Host Defense Peptides

• Main Authors: Ali Javed (Author), Melanie D. Balhuizen (Author), Arianne Pannekoek (Author), Floris J. Bikker (Author), Dani A. C. Heesterbeek (Author), Henk P. Haagsman (Author), Femke Broere (Author), Markus Weingarth (Author), Edwin J. A. Veldhuizen (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The binding of Host Defense Peptides (HDPs) to the endotoxin of Gram-negative bacteria has important unsolved aspects. For most HDPs, it is unclear if binding is part of the antibacterial mechanism or whether LPS actually provides a protective layer against HDP killing. In addition, HDP binding to L...