Enhancement of the Solubility and Dissolution Rate of Telmisartan by Surface Solid Dispersions Employing Superdisintegrants, Hydrophilic Polymers and Combined Carriers

• Váldodahkkit: Reem A. Aldeeb (Dahkki), Mohamed Farid El-Miligi (Dahkki), Mohamed El-Nabarawi (Dahkki), Randa Tag (Dahkki), Hany M. S. Amin (Dahkki), A. A. Taha (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2022-11-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Telmisartan (Tel) is a potent antihypertensive drug with a very poor aqueous solubility, especially in pH ranging from 3 to 9 (i.e., biological fluids) that results in poor bioavailability. Our aim was to improve Tel solubility and dissolution rates without the need for expensive multistep procedure...