Enhancement of the Solubility and Dissolution Rate of Telmisartan by Surface Solid Dispersions Employing Superdisintegrants, Hydrophilic Polymers and Combined Carriers

Enhancement of the Solubility and Dissolution Rate of Telmisartan by Surface Solid Dispersions Employing Superdisintegrants, Hydrophilic Polymers and Combined Carriers

Telmisartan (Tel) is a potent antihypertensive drug with a very poor aqueous solubility, especially in pH ranging from 3 to 9 (i.e., biological fluids) that results in poor bioavailability. Our aim was to improve Tel solubility and dissolution rates without the need for expensive multistep procedure...

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Bibliographic Details
Main Authors: Reem A. Aldeeb (Author), Mohamed Farid El-Miligi (Author), Mohamed El-Nabarawi (Author), Randa Tag (Author), Hany M. S. Amin (Author), A. A. Taha (Author)
Format: Book
Published: MDPI AG, 2022-11-01T00:00:00Z.
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