Genetic Interaction-Based Biomarkers Identification for Drug Resistance and Sensitivity in Cancer Cells

• Main Authors: Yue Han (Author), Chengyu Wang (Author), Qi Dong (Author), Tingting Chen (Author), Fan Yang (Author), Yaoyao Liu (Author), Bo Chen (Author), Zhangxiang Zhao (Author), Lishuang Qi (Author), Wenyuan Zhao (Author), Haihai Liang (Author), Zheng Guo (Author), Yunyan Gu (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer cells generally harbor hundreds of alterations in the cancer genomes and act as crucial factors in the development and progression of cancer. Gene alterations in the cancer genome form genetic interactions, which affect the response of patients to drugs. We developed an algorithm that mines c...