Targeting Phosphorylation of p21-activated Kinase 1 at Thr423 Induces Cell Cycle Arrest and Apoptosis in Cutaneous T-cell Lymphoma Cells

• Main Authors: Yimeng Wang (Author), Weiwei Li (Author), Qian Zhang (Author), Xiaoguang Gu (Author), Xinglan He (Author), Yuehua Men (Author), Chunlei Zhang (Author)
• Format: Book
• Published: Medical Journals Sweden, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cutaneous T-cell lymphoma (CTCL) represents a rare group of extranodal T-cell lymphoproliferative diseases. Due to poor clinical outcome of CTCL, there is an urgent need for new and improved therapies. A small molecule, IPA-3, which inhibits p21-activated kinase 1 (PAK1), has shown therapeutic poten...