Biliary excretion and enterohepatic circulation of thienorphine and its glucuronide conjugate in rats

• Main Authors: Jingting Deng (Author), Xiaomei Zhuang (Author), Guolin Shen (Author), Hua Li (Author), Zehui Gong (Author)
• Format: Bog
• Udgivet: Elsevier, 2012-04-01T00:00:00Z.
• Fag: article
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Thienorphine (TNP) is a new partial opioid agonist currently developed as a promising drug candidate with the intended clinical indication for the treatment of opioid dependence. The pharmacokinetic profile and biliary excretion of TNP and its glucuronide conjugate (TNP-Glu) were investigated after...