Spectroscopic and thermodynamic characterization of the interaction of a new synthesized antitumor drug candidate 2H4MBBH with human serum albumin

• Main Authors: Silviya Abarova (Author), Katerina Stoitchkova (Author), Svetlin Tzonev (Author), Maria Argirova (Author), Denitsa Yancheva (Author), Neda Anastassova (Author), Boris Tenchov (Author)
• Format: Book
• Published: Pensoft Publishers, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present work we studied the interactions of a newly synthesized drug candidate, 2-(2-hydroxy-4-methoxybenzylidene)-1-(1H-benzimidazol-2-yl)hydrazine (2H4MBBH), with human serum albumin (HSA) by fluorescence spectroscopy. 2H4MBBH-HSA binding parameters were assessed by fluorescence quenching s...