Prodiginines Postpone the Onset of Sporulation in <i>Streptomyces coelicolor</i>

• Main Authors: Elodie Tenconi (Author), Matthew Traxler (Author), Déborah Tellatin (Author), Gilles P. van Wezel (Author), Sébastien Rigali (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bioactive natural products are typically secreted by the producer strain. Besides that, this allows the targeting of competitors, also filling a protective role, reducing the chance of self-killing. Surprisingly, DNA-degrading and membrane damaging prodiginines (PdGs) are only produced intracellular...