A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer's disease

• Main Authors: Yuya Asanomi (Author), Daichi Shigemizu (Author), Akinori Miyashita (Author), Risa Mitsumori (Author), Taiki Mori (Author), Norikazu Hara (Author), Kaoru Ito (Author), Shumpei Niida (Author), Takeshi Ikeuchi (Author), Kouichi Ozaki (Author)
• Format: Book
• Published: BMC, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Late-onset Alzheimer's disease (LOAD), the most common form of dementia, results from complicated interactions among multiple environmental and genetic factors. Despite recent advances in genetic analysis of LOAD, more than half of the heritability for the disease remains un...