Discovery of novel coumarin derivatives as potent and orally bioavailable BRD4 inhibitors based on scaffold hopping

• Main Authors: Zhimin Zhang (Author), Lili Gu (Author), Beibei Wang (Author), Wenhai Huang (Author), Yanmin Zhang (Author), Zhen Ma (Author), Shenxin Zeng (Author), Zhengrong Shen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bromodomain and extra-terminal (BET) bromodomains, particularly BRD4, have been identified as promising therapeutic targets in the treatment of many human disorders such as cancer, inflammation, obesity, and cardiovascular disease. Recently, the discovery of novel BRD4 inhibitors has garnered su...