Tetramethylpyrazine inhibits ferroptosis in spinal cord injury by regulating iron metabolism through the NRF2/ARE pathway

• 主要な著者: Jingwei Tao (著者), Jingya Zhou (著者), Hanjie Zhu (著者), Lin Xu (著者), Jizhou Yang (著者), Xiaohong Mu (著者), Xiao Fan (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

BackgroundTetramethylpyrazine (TMP) is a natural alkaloid compound with antioxidant and neuroprotective effects. We hypothesized that TMP could exert neuroprotective effects by inhibiting ferroptosis through modulating iron metabolism, but its mechanism is unclear. Through in vivo and in vitro exper...