Development of novel prime-boost strategies based on a tri-gene fusion recombinant L. tarentolae vaccine against experimental murine visceral leishmaniasis.

• Main Authors: Noushin Saljoughian (Author), Tahereh Taheri (Author), Farnaz Zahedifard (Author), Yasaman Taslimi (Author), Fatemeh Doustdari (Author), Azam Bolhassani (Author), Delaram Doroud (Author), Hiva Azizi (Author), Kazem Heidari (Author), Mohammad Vasei (Author), Nabiollah Namvar Asl (Author), Barbara Papadopoulou (Author), Sima Rafati (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Visceral leishmaniasis (VL) is a vector-borne disease affecting humans and domestic animals that constitutes a serious public health problem in many countries. Although many antigens have been examined so far as protein- or DNA-based vaccines, none of them conferred complete long-term protection. Th...