A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer

• Main Authors: Mara Gladstone (Author), Barbara Frederick (Author), Di Zheng (Author), Anthony Edwards (Author), Petros Yoon (Author), Stefanie Stickel (Author), Tessie DeLaney (Author), Daniel C. Chan (Author), David Raben (Author), Tin Tin Su (Author)
• Format: Book
• Published: The Company of Biologists, 2012-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY We described previously a screening protocol in Drosophila melanogaster that allows us to identify small molecules that increase the killing effect of ionizing radiation in vivo in a multicellular context. The ability of this screen to identify agents that enhance the effect of radiation in...