Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold

• Main Authors: Zehua Sun (Author), Chuan Chen (Author), Wei Li (Author), David R. Martinez (Author), Aleksandra Drelich (Author), Du-San Baek (Author), Xianglei Liu (Author), John W. Mellors (Author), Chien-Te Tseng (Author), Ralph S. Baric (Author), Dimiter S. Dimitrov (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Effective therapies are urgently needed for COVID-19. Here we describe the identification of a new stable human immunoglobulin G1 heavy-chain variable (VH) domain scaffold that was used for the construction of a large library, lCAT6, of engineered human VHs. This library was panned against the recep...