Activation of Peroxisome Proliferator-Activated Receptor γ by Rosiglitazone Inhibits Lipopolysaccharide-Induced Release of High Mobility Group Box 1

• Main Authors: Jung Seok Hwang (Author), Eun Sil Kang (Author), Sun Ah Ham (Author), Taesik Yoo (Author), Hanna Lee (Author), Kyung Shin Paek (Author), Chankyu Park (Author), Jin-Hoi Kim (Author), Dae-Seog Lim (Author), Han Geuk Seo (Author)
• Format: Book
• Published: Hindawi Limited, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peroxisome proliferator-activated receptors (PPARs) are shown to modulate the pathological status of sepsis by regulating the release of high mobility group box 1 (HMGB1), a well-known late proinflammatory mediator of sepsis. Ligand-activated PPARs markedly inhibited lipopolysaccharide- (LPS) induce...