Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1

• Autors principals: Bianka Edina Herman (Autor), Anita Kiss (Autor), János Wölfling (Autor), Erzsébet Mernyák (Autor), Mihály Szécsi (Autor), Gyula Schneider (Autor)
• Format: Llibre
• Publicat: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a key enzyme in the biosynthesis of 17β-estradiol. Novel estrone-based compounds bearing various 15β-oxa-linked substituents and hydroxy, methoxy, benzyloxy, and sulfamate groups in position C3 as potential 17β-HSD1 inhibitors have been synthesiz...