Electrochemical Characterization of Central Action Tricyclic Drugs by Voltammetric Techniques and Density Functional Theory Calculations

• Main Authors: Edson Silvio Batista Rodrigues (Author), Isaac Yves Lopes de Macêdo (Author), Larissa Lesley da Silva Lima (Author), Douglas Vieira Thomaz (Author), Carlos Eduardo Peixoto da Cunha (Author), Mayk Teles de Oliveira (Author), Nara Ballaminut (Author), Morgana Fernandes Alecrim (Author), Murilo Ferreira de Carvalho (Author), Bruna Guimarães Isecke (Author), Karla Carneiro de Siqueira Leite (Author), Fabio Bahls Machado (Author), Freddy Fernandes Guimarães (Author), Ricardo Menegatti (Author), Vernon Somerset (Author), Eric de Souza Gil (Author)
• Format: Book
• Published: MDPI AG, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This work details the study of the redox behavior of the drugs cyclobenzaprine (CBP), amitriptyline (AMP) and nortriptyline (NOR) through voltammetric methods and computational chemistry. Results obtained in this study show that the amine moiety of each compound is more likely to undergo oxidation a...