Triptolide enhances carboplatin-induced apoptosis by inhibiting nucleotide excision repair (NER) activity in melanoma

• Main Authors: Geng Wang (Author), Hongmin Guo (Author), Yan Ren (Author), Weiyi Chen (Author), Yixuan Wang (Author), Jianing Li (Author), Hua Liu (Author), Jingjun Xing (Author), Yanru Zhang (Author), Na Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Carboplatin (CBP) is a DNA damaging drug used to treat various cancers, including advanced melanoma. Yet we still face low response rates and short survival due to resistance. Triptolide (TPL) is considered to have multifunctional antitumor effects and has been confirmed to enhance the...