Probing mutation-induced conformational transformation of the GTP/M-RAS complex through Gaussian accelerated molecular dynamics simulations
Mutations highly affect the structural flexibility of two switch domains in M-RAS considered an important target of anticancer drug design. Gaussian accelerated molecular dynamics (GaMD) simulations were applied to probe the effect of mutations P40D, D41E, and P40D/D41E/L51R on the conformational tr...
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Format: | Book |
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Taylor & Francis Group,
2023-12-01T00:00:00Z.
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Connect to this object online.3rd Floor Main Library
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A1234.567 |
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Copy 1 | Available |