Mouse promyelocytic leukemia zinc finger protein (PLZF) regulates hepatic lipid and glucose homeostasis dependent on SIRT1

• Main Authors: Huiling Hu (Author), Nannan Sun (Author), Haiyan Du (Author), Yuqing He (Author), Kunyi Pan (Author), Xiuli Liu (Author), Xiaoxia Lu (Author), Jie Wei (Author), Mianmian Liao (Author), Chaohui Duan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous studies have demonstrated that promyelocytic leukemia zinc finger protein (PLZF) promotes the expression of gluconeogenic genes and hepatic glucose output, which leads to hyperglycemia. However, the role played by PLZF in regulating lipid metabolism is not known. In this study, we aimed to...