Highly protein-loaded melt extrudates produced by small-scale ram and twin-screw extrusion - evaluation of extrusion process design on protein stability by experimental and numerical approaches

• मुख्य लेखकों: Katharina Dauer (लेखक), Kevin Kayser (लेखक), Felix Ellwanger (लेखक), Achim Overbeck (लेखक), Arno Kwade (लेखक), Heike P. Karbstein (लेखक), Karl G. Wagner (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Understanding of generation, extent and location of thermomechanical stress in small-scale (< 3 g) ram and twin-screw melt-extrusion is crucial for mechanistic correlations to the stability of protein particles (lysozyme and BSA) in PEG-matrices. The aim of the study was to apply and correlate ex...