Si-Ni-San alleviates early life stress-induced depression-like behaviors in adolescence via modulating Rac1 activity and associated spine plasticity in the nucleus accumbens

• Main Authors: Lihong Ye (Author), Jiayi Wu (Author), Zuyi Liu (Author), Di Deng (Author), Shasha Bai (Author), Lei Yang (Author), Yao Xuan (Author), Zehao Liu (Author), Yafei Shi (Author), Zhongqiu Liu (Author), Rong Zhang (Author), Jinlan Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Early life stress (ELS) is a major risk factor for depression in adolescents. The nucleus accumbens (NAc) is a key center of the reward system, and spine remodeling in the NAc contributes to the development of depression. The Si-Ni-San formula (SNS) is a fundamental prescription for trea...