Tenofovir Hot-Melt Granulation using Gelucire^® to Develop Sustained-Release Vaginal Systems for Weekly Protection against Sexual Transmission of HIV

• Main Authors: Fernando Notario-Pérez (Author), Raúl Cazorla-Luna (Author), Araceli Martín-Illana (Author), Roberto Ruiz-Caro (Author), Juan Peña (Author), María-Dolores Veiga (Author)
• 格式: 圖書
• 出版: MDPI AG, 2019-03-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Hot-melt granulation is a technique used to obtain granules by dispersing a drug in polymers at a high temperature. Tenofovir, an antiretroviral drug with proven activity as a vaginal microbicide, was dispersed in melted Gelucire^® (or a mixture of different Gelucire<sup>...