Hybrid Caffeic Acid-Based DHFR Inhibitors as Novel Antimicrobial and Anticancer Agents

Hybrid Caffeic Acid-Based DHFR Inhibitors as Novel Antimicrobial and Anticancer Agents

A novel series of 1,2,4-triazole analogues of caffeic acid was designed, synthesized, characterized, and assessed for their capacity to inhibit DHFR, as well as their anticancer and antimicrobial properties. A molecular docking analysis was conducted on DHFR, utilizing PDB IDs 1U72 and 2W9S, aiming...

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Main Authors: Renu Sehrawat (Author), Ritu Pasrija (Author), Priyanka Rathee (Author), Deepika Kumari (Author), Anurag Khatkar (Author), Esra Küpeli Akkol (Author), Eduardo Sobarzo-Sánchez (Author)
Format: Book
Published: MDPI AG, 2024-05-01T00:00:00Z.
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