A Plant like Cytochrome P450 Subfamily CYP710C1 Gene in Leishmania donovani Encodes Sterol C-22 Desaturase and its Over-expression Leads to Resistance to Amphotericin B.

• Main Authors: Ruby Bansal (Author), Shib Sankar Sen (Author), Rohini Muthuswami (Author), Rentala Madhubala (Author)
• 格式: 圖書
• 出版: Public Library of Science (PLoS), 2019-04-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

BACKGROUND:Leishmania donovani is a protozoan parasite, a primary causative agent of visceral leishmaniasis. Sterol produced via the mevalonate pathway, show differences in composition across biological kingdoms. The specific occurrence of Δ22-unsaturated sterols, containing a double bond at the C-2...