A novel zebrafish intestinal tumor model reveals a role for cyp7a1-dependent tumor-liver crosstalk in causing adverse effects on the host

• Main Authors: Sora Enya (Author), Koichi Kawakami (Author), Yutaka Suzuki (Author), Shinpei Kawaoka (Author), Almut Schulze (Author), Mariia Yuneva (Author)
• Format: Book
• Published: The Company of Biologists, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The nature of host organs and genes that underlie tumor-induced physiological disruption on the host remains ill-defined. Here, we establish a novel zebrafish intestinal tumor model that is suitable for addressing this issue, and find that hepatic cyp7a1, the rate-limiting factor for synthesizing bi...