Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis.

• Main Authors: Stephen M Christensen (Author), Ashton T Belew (Author), Najib M El-Sayed (Author), Wagner L Tafuri (Author), Fernando T Silveira (Author), David M Mosser (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diffuse cutaneous leishmaniasis (DCL) is a rare form of leishmaniasis where parasites grow uncontrolled in diffuse lesions across the skin. Meta-transcriptomic analysis of biopsies from DCL patients infected with Leishmania amazonensis demonstrated an infiltration of atypical B cells producing a sur...