Sesquiterpene lactone derivatives of KSL-B targeting Arf1-Big1Sec7 interaction

• Main Authors: Sergio Ortiz (Author), François Peurois (Author), Euzébio Guimarães Barbosa (Author), Mohamed Selkti (Author), Pascale Lemoine (Author), Jacqueline Cherfils (Author), Raphaël Grougnet (Author), Sabrina Boutefnouchet (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The GDP/GTP conformational change of Arf GTPase proteins by different guanine exchange factor GEFs proteins (Big1Sec7, ARNOSec7, Brag1Sec7, etc.), modulates important eukaryotes cell functions, such as secretion, endocytosis, phagocytosis, cytokinesis and cell adhesion. The overproduction and overac...