Targeting Leishmania infantum Mannosyl-oligosaccharide glucosidase with natural products: potential pH-dependent inhibition explored through computer-aided drug design

• Main Authors: Luis Daniel Goyzueta-Mamani (Author), Haruna Luz Barazorda-Ccahuana (Author), Mayron Antonio Candia-Puma (Author), Alexsandro Sobreira Galdino (Author), Ricardo Andrez Machado- (Author), Rodolfo Cordeiro Giunchetti (Author), José L. Medina-Franco (Author), Mónica Florin-Christensen (Author), Eduardo Antonio Ferraz Coelho (Author), Miguel Angel Chávez-Fumagalli (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Visceral Leishmaniasis (VL) is a serious public health issue, documented in more than ninety countries, where an estimated 500,000 new cases emerge each year. Regardless of novel methodologies, advancements, and experimental interventions, therapeutic limitations, and drug resistance are still chall...