Inflammatory-Related P62 Triggers Malignant Transformation of Mesenchymal Stem Cells through the Cascade of CUDR-CTCF-IGFII-RAS Signaling

• Main Authors: Xiaoru Xin (Author), Chen Wang (Author), Zhuojia Lin (Author), Jie Xu (Author), Yanan Lu (Author), Qiuyu Meng (Author), Xiaonan Li (Author), Yuxin Yang (Author), Qidi Zheng (Author), Xin Gui (Author), Tianming Li (Author), Hu Pu (Author), Wujun Xiong (Author), Jiao Li (Author), Song Jia (Author), Dongdong Lu (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammatory and autophagy-related gene P62 is highly expressed in most human tumor tissues. Herein, we demonstrate that P62 promotes human mesenchymal stem cells' malignant transformation via the cascade of P62-tumor necrosis factor alpha (TNF-α)-CUDR-CTCF-insulin growth factor II (IGFII)-H-Ra...