Development and evaluation of candidate subunit vaccine against botulinum neurotoxin serotype B

• Main Authors: Dan-Yang Shi (Author), Bo-Yang Chen (Author), Yun-Yun Mao (Author), Guo Zhou (Author), Jian-Sheng Lu (Author), Yun-Zhou Yu (Author), Xiao-Wei Zhou (Author), Zhi-Wei Sun (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Botulinum neurotoxins (BoNTs) are potential biological weapons because of their high toxicity and mortality. Vaccination is an effective strategy to prevent botulism. The carboxyl-terminus of the heavy chain (Hc domain) is nontoxic and sufficient to generate protective immune responses against natur...