Nimbolide targeting SIRT1 mitigates intervertebral disc degeneration by reprogramming cholesterol metabolism and inhibiting inflammatory signaling

• Main Authors: Yun Teng (Author), Yixue Huang (Author), Hao Yu (Author), Cenhao Wu (Author), Qi Yan (Author), Yingjie Wang (Author), Ming Yang (Author), Haifeng Xie (Author), Tianyi Wu (Author), Huilin Yang (Author), Jun Zou (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation, abnormal cholesterol metabolism, and macrophage infiltration are involved in the destruction of the extracellular matrix of the nucleus pulposus (NP), culminating in intervertebral disc degeneration (IDD). Whether nimbolide (Nim), a natural extract, can alleviate IDD is unclear. In thi...